Transposon-mediated insertional mutagenesis unmasks recessive insecticide resistance in the aphid <i>Myzus persicae</i>

Significance The ability to control damaging plant pests and vectors of animal disease is threatened by the emergence insecticide resistance. Developing effective strategies prevent, slow, or overcome resistance requires an understanding underlying genetic mechanisms. Here, we present example evolution arising from transposable element–mediated disruption a dominant insecticide-susceptible allele, resulting in expression recessive allele potent Our findings demonstrate how adaptive potential elements can be revealed environmental perturbation that this have profound unexpected impacts on They also illustrate combinations mutations individually confer no fitness benefit interact provide strong context-dependent benefits.